Acebutolol (Sectral ®)

Oral: 400-800 mg/day
Maximum 1200 mg/day

Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal

Atenolol (Tenormin ®)

Oral: 50 mg once daily; may increase to 100 mg/day

Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Salicylates - may reduce anti-hypertensive effects of beta-blockers

Betaxolol (Betoptic®; Kerlone ®)

Oral: 10 mg/day; may increase up to 20 mg/day after 7-14 days in order to obtain desired response

Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Salicylates-may reduce anti-hypertensive effects of beta-blockers

Bisoprolol (Zebeta ™)

Oral: 5 mg once daily; may increase to 10 to 20 mg, daily, if necessary

Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Salicylates-may reduce anti-hypertensive effects of beta-blockers

Carteolol (Cartrol ®)

Oral: 2.5 mg as a single daily dose
Maintenance dose-normally 2.5-5 mg once daily

Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Salicylates-may reduce anti-hypertensive effects of beta-blockers

Carvedilol (Coreg®)

Oral:  6.25 mg twice daily;

Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Increased cyclosporine levels in the blood
Salicylates - may reduce anti-hypertensive effects of beta-blockers

Labetalol (Trandate®, Normodyne®)

Oral: 100 mg twice daily; may be increased as needed every 2-3 days by 100 mg until desired response achieved; usual dosage-200-400 mg twice daily

Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Cimetidine – increased blood levels of labetalol
Halothane anesthesia - excessive low blood pressure may occur
Sulfonylurea hypoglycemic drugs – beta-blockers may mask low blood sugar
Salicilyates  -may reduce antihypertensive effects of beta-blockers

(Metoprolol
Lopressor®)

Oral: 100-450 mg/day in 2-3 divided doses; begin with 50 mg twice daily and increase doses weekly to desired effect

Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Sulfonylurea hypoglycemic drugs - beta-blockers may mask low blood sugar

Nadolol (Corgard®)

Oral: Initial-40 mg/day; increase dosage gradually by 40-80 mg increments at 3-7 day intervals until desired effect is achieved

Albuterol - effects may be blocked by beta-blockers
Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Sulfonylurea hypoglycemic drugs - beta-blockers may mask low blood sugar

Penbutolol (Levatol®)

Oral:
Angina pectoris:
10-40 mg once dailyHypertension:usual dose-20 mg once daily; higher doses (40-80 mg) have not demonstrated greater effectiveness

Clonidine - hypertensive crisis upon drug withdrawal
Verapamil - may cause low blood pressure and slow heart rate

Pindolol (Visken®)

Oral:
Initial-5 mg twice daily; increase as necessary by 10 mg/day every 3-4 weeks
Maximum daily dosage- 60 mg/day

Albuterol-Its effects may be blocked by beta-blockers
Alpha blockers – increased risk of low pressure upon standing
Clonidine - hypertensive crisis upon drug withdrawal
Sulfonylurea hypoglycemic drugs - beta-blockers may mask low blood sugar
Epinephrine-pindolol may cause hypertension

Propranolol (Inderal®, various)

Oral: Initial-40 mg twice daily; increase dosage every 3-7 days; usual dose is less than or equal to 320 mg divided in 2-3 doses/day; Maximum daily dose-640 mg/day

Albuterol-Its effects may be blocked by beta-blockers
Reserpine-increases the effects of propranolol
Sulfonylurea hypoglycemic drugs - beta-blockers may mask low blood sugar

Propranolol long-acting (Inderal-LA®)

Sotalol (Betaspace®)

Oral: Initial-80 mg twice daily; dose may be increased gradually to 240-320 mg/day

Antacids(aluminum & magnesium)-decrease sotalol levels in the blood
Clonidine - hypertensive crisis upon drug withdrawal

Timolol (Biocadren®)

Oral:
Initial-10 mg twice daily; increase gradually every 7 days; usual dosage=20-40 mg/day in 2 divided doses
Maximum dosage-60 mg/day

Sulfonylurea hypoglycemic drugs - beta-blockers may mask low blood sugar