Jiajin Yang, MD
Assistant Professor of Research

Email: jjyang@med.unc.edu
Phone: (919) 966-2561 x 281
Fax: (919) 966-4251
Office Location: 5004 Burnett Womack

Specialty Areas: ANCA-associated disease: gene expression and regulation, antigens and antibodies purification and biology, leukocyte activation, endothelial apoptosis and animal surgery.

Chronology: MD: Peking University, 1970; Physician: Xian Railway Central Hospital, 1970-80; Attending Nephrologist: Xian Railway Central Hospital, 1981-9; Visiting Scholar: University of North Carolina, 1989-91; Post-Doctoral Research Associate: University of North Carolina, 1991-5; Research Associate: University of North Carolina, 1995-2001;Assistant Professor of Research: University of North Carolina, 2001-Present

Dr. Yang's research focuses on the pathogenesis of ANCA associated glomerulophritis and vasculitis. She investigates the leukocyte activation, including neutrophils and monocytes activated by ANCA and T-cell proliferated by complementary PR3 peptide, and ANCA antigens, PR3 and MPO, directly induce vascular endothelial injury. She also research changes of gene expression levels in leukocytes of patients with ANCA-disease, the causes of these changes and the relation with clinic characteristics.

Selected Bibliography:

Jiajin Yang, David J Bautz, Sofia Lionaki, Susan L Hogan, Hyunsook Chin, Roland M Tisch, John L Schmitz, Barrak M Pressler, J Charles Jennette, Ronald J Falk, and Gloria A Preston. ANCA Patients have T cells responsive to complementary PR-3 antigen. Kidney International 74(9): 1159-1169, 2008.

Jiajin Yang, William F Pendergraft, David A Alcorta, Patrick H Nachman, Susan L Hogan, Robin P Thomas, Pamela Sullivan, J Charles Jennette, Ronald J Falk and Gloria A Preston. Circumvention of normal constraints on granule protein gene expression in peripheral blood neutrophils and monocytes of patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. J Am Soc Nephrol 15:2103-2114, 2004.

Jiajin Yang, Gloria A Preston, David A Alcorta, Iwao Waga, William E Munger, Susan L Hogan, Stephen B Sekura, Brian D Phillips, Robin P Thomas, J Charles Jennette, and Ronald J Falk. Expression Profile of leukocyte genes activated by anti-neutrophil cytoplasmic autoantibodies (ANCA). International Society of Nephrology 62:1638-1649, 2002.

Jiajin Yang, Gloria A Preston, William F Pendergraft, Marten Segelmark, Peter Heeringa, Susan L Hogan, J Charles Jennette and Ronald J Falk. Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants. Am J Pathol 158:581-592, 2001.

Jiajin Yang, Ralph Kettritz, Ronald J Falk, J Charles Jennette and Marcia L Gaido. Apoptosis of Endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase. Am J Pathol 149:1617-1626, 1996.

Jiajin Yang, Robin H Tuttle, Susan L Hogan, Joe G Taylor, Brian D Phillips, Ronald J Falk and J Charles Jennette. Target antigens for anti-neutrophil cytoplasmic autoantibodies (ANCA) are on the surface of primed and apoptotic but not unstimulated neutrophils. Clin Exp Immunol 121:165-172, 2000.

Jiajin Yang and William F Finn. Effect of oxypurinol on cyclosporine toxicity in cultured EA, LLC-PK1 and MDCK cells. Renal Failure 20:85-101, 1998.

Jiajin Yang, Robin H Tuttle, Ronald J Falk and J Charles Jennette. Frequency of anti-bactericidal/permeability-increasing protein (BPI) and anti-azurocidin in patients with renal disease. Clin Exp Immunol 105:125-131, 1996.

Jiajin Yang, J Charles Jennette and Ronald J Falk. Immune complex glomerulonephritis is induced in rats immunized with heterologous myeloperoxidase. Clin Exp Immunol 97:466-473, 1994.

 

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