John Edwards

Email: jedwards@med.unc.edu
Phone: (919) 966-2561 x261
Fax: (919) 966-4251
Office: 5020 Burnett-Womack

John C. Edwards, MD, PhD
Associate Professor of Medicine

Specialty Areas: Disorders of electrolyte and acid/base metabolism, general nephrology and hypertension, molecular biology of ion transport in the kidney.

Chronology: BS with honors and with distinction in biochemisty, University of Illinois, Urbana IL, 1978; PhD in biochemistry, University of Chicago, Chicago IL 1983; MD with honors, University of Chicago, Chicago IL 1985; Internship and Residency in Internal Medicine, Presbyterian Hospital, New York, NY, 1985-1987;Nephrology Fellowship, Columbia University, New York, NY 1987-1988; Assistant Professor of Clinical Medicine, Columbia University, New York NY 1988-1990; Assistant Professor of Medicine, Renal Division, Washington University, St. Louis, MO, 1990-1999; Associate Professor of Medicine, Renal Division, St. Louis University; Director of Nephrology Service, St. Louis VA Hospital, St. Louis MO 1999-2005; Associate Professor of Medicine, University of North Carolina, Chapel Hill NC, 2005-present.

Dr. Edwards’ clinical expertise is in the general management of acute and chronic renal disease, with particular interest in disorders of fluid and electrolyte metabolism. His research is focused on biochemistry and molecular biology of ion transporters, particularly the CLIC family of chloride channels and their roles in normal cell physiology and disease.


Selected Bibliography:

Landry D, Sullivan S, Nicolaides M, Redhead C, Edelman A, Field M, Al-Awqati Q, Edwards JC: Molecular cloning and characterization of p64, a chloride channel protein from kidney microsomes.  J. Biol. Chem. 1993;268:14948-14955.

Van Adelsberg J, Edwards JC, Takito J, Kiss B, Al-Awqati Q:  An induced extracellular matrix protein reverses the polarity of band 3 in intercalated epithelial cells.  Cell 1994;76:1053-1061.

Redhead C, Sullivan SK, Kosecki C, Fugiwara K, and Edwards JC.  Subcellular distribution and targeting of the intracellular chloride channel, p64. Mol. Biol. Cell 1997; 8:691-704.

Schlesinger PH, Blair HC, Teitelbaum SL, and Edwards JC :  Characterization of the osteoclast ruffled border chloride channel and its role in bone resorption.  J. Biol. Chem. 1997; 272:18636-18643.

Edwards JC, Tulk BM, and Schlesinger P.  Functional expression of p64, an intracellular chloride channel.  J. Mem. Biol.1998; 163: 119-128.

Tulk BM, and Edwards JC.  NCC27, a homolog of intracellular chloride channel p64, is expressed in the brush border of renal proximal tubule.  Am. J. Physiol. (Renal) 1998; 274: F1140-F1149

Edwards JC.  A novel member of the p64 Cl channel family:  subcellular distribution and nephron segment specific expresssion. Am. J. Physiol. (Renal) 1998; 276: F398-F408.

Tulk BM, Schlesinger, PH, and Edwards, JC.  CLIC-1 Functions as a Chloride Channel when Expressed and Purified from Bacteria.  J. Biol. Chem. 2000; 275: 26986-26993.

Edwards, J.C., and Kapadia, S.  The bovine kidney microsomal chloride channel p64 is regulated by p59-fyn, a src family tryosine kinase. J. Biol. Chem. 2000; 275: 31826-31832.

Tulk, B.M., Kapadia, S. and Edwards, J.C.  CLIC-1 Directly Inserts From the Aqueous Phase Into Phospholipid Membranes Where it Functions as a Chloride Channel.  Am. J. Physiol.: Cell Physiol. 2002; 282: C1103-1112.

Berryman, M., Bruno, J., Price, J., and Edwards, J.C.  CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.  J. Biol. Chem. 2004; 279: 34794-34801.

Al-Aly, Z., and Edwards, J.  Vascular Biology in uremia: insights into novel mechanisms of vascular injury. Adv. Chronic Kidney Dis. 2004 11: 310-318.

Edwards, J.C., Cohen, C., Xu, Charles W. and Schlesinger, P.H.  Chloride Channel and c-Src Control of Osteoclast HCl Transport and Bone Resorption. J. Biol. Chem. 2006 (in press).




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