William J. Arendshorst, Ph.D
Professor of Cell & Molecular Physiology; Director, Laboratory of Renal Physiology and Vascular Biology

Email: arends@med.unc.edu
Phone: (919) 966-1067
Fax: (919) 966-6927
Office: 6341-B Medical Biomolecular Research Building
Web Home Page

Specialty Areas: Renal Circulation, Vascular Reactivity and Signaling, Genetic Hypertension, Paracrine and autacrine agents.

Chronology: BA, DePauw University, 1966; PhD, Indiana University, 1970; Postdoctoral Fellow, Indiana University 1970-71; Postdoctoral Fellow, UNC-Chapel Hill, 1971–74; Assistant & Associate Professor, UNC-Chapel Hill, 1974–86; Professor of Physiology, UNC-Chapel Hill, 1986 - present. 

Dr. Arendshorst’s research addresses issues centering on renal vascular reactivity to angiotensin II, endothelin, and thromboxane in genetic hypertension with particular emphasis on the involvement of nitric oxide and reactive oxygen species in the signaling pathways.  Receptor subtypes and intracellular messenger systems are assessed.  Investigations include in vivo blood flow experiments on whole animals.  Calcium measurements in isolated microvessels and smooth muscle cells probe calcium entry channels and mobilization/release channels.. Expression is studies in terms of receptors and enzyme mRNA and protein levels in isolated renal microvessels. 

Selected Bibliography:

Arendshorst, W.J. and L.G. Navar.  Renal Circulation and Glomerular Hemodynamics.  Chapter 2, Eighth Edition of Diseases of the Kidney, edited by R.W. Schrier, Lipincott Williams and Wilkins.  2006, In Press.  

Fellner, SK and WJ Arendshorst.  Endothelin A and B receptors, superoxide and Ca2+ signaling in afferent arterioles.  Am J Physiol Renal Physiol.  In Press. 

Peng Z, and WJ Arendshorst.  Increased expression and activity of phospholipase C in renal arterioles of young spontaneously hypertensive rats.  Am J Hypertension.  In Press. 

Armin Just A and WJ Arendshorst.  Nitric Oxide blunts myogenic autoregulation in rat renal but not skeletal muscle circulation via tubuloglomerular feedback.  J. Physiol. 569: 959-974, 2005.  http://jp.physoc.org/cgi/reprint/569/3/959 

Fellner, SK and WJ Arendshorst.  Angiotensin II, reactive oxygen species and Ca2+ signaling in afferent arterioles  Am J Physiol Renal Physiol.  289: F1012-F1019, 2005.  http://ajprenal.physiology.org/cgi/reprint/00144.2005v1 

Boffa, JJ, and W.J. Arendshorst.  Maintenance of renal vascular reactivity contributes to acute renal failure during endotoxemic shock. J Amer Soc Nephrol 16: 117-124, 2005.  http://www.jasn.org/cgi/content/full/16/1/117 

Boffa, J.J., A. Just, and W.J. Arendshorst.  Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice.  J Amer Soc Nephrol, 15:2358-2365, 2004. (Note Basic Science Highlight on p. 2343)   http://www.jasn.org/cgi/content/full/15/9/2358 

Facemire, C, WJ Arendshorst.  Calmodulin mediates norepinephrine-induced receptor-operated calcium in preglomerular resistance arteries.  Am J Physiol Renal Physiol 289: F127-F136, 2005.  http://ajprenal.physiology.org/cgi/content/full/289/1/F127 

Just, A, AJM Olson, JR Falck, WJ Arendshorst.  Nitric oxide and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat.   Am J Physiol Regul Integr Comp Physiol 288:R1168-R1177, 2005.http://ajpregu.physiology.org/cgi/content/full/288/5/R1168 

Vagnes, O, FH Hansen, JJ Feng, BM Iversen, and WJ Arendshorst.  Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states.  Am J Physiol – Renal Physiol 288: F1249-F1256, 2005.  http://ajprenal.physiology.org/cgi/content/full/288/6/F1249 

Fellner, SK and WJ Arendshorst.  Angiotensin II Ca2+ signaling in rat afferent arterioles: Stimulation of cyclic ADP ribose and IP3 pathways.  Am J Physiol Renal Physiol  288: F785-F791, 2005.  http://ajprenal.physiology.org/cgi/reprint/288/4/F785 

Fellner, SK and WJ Arendshorst.  Endothelin A and B receptors on preglomerular vascular smooth muscle cells.  Kidney Int.  65: 1810-1817, 2004.  Click here 

Salomonsson, M, CM Sorensen, WJ Arendshorst, J Steendahl, and N-H Holstein-Rathlou.  Calcium handling in afferent arterioles.  Acta Physiol. Scand., 181: 421-429, 2004. Click here 

Salomonsson, M. and W.J. Arendshorst.  Effect of tyrosine kinase blockade on norepinephrine-induced cytosolic calcium response in rat afferent arterioles.  Am. J. Physiol. – Renal Physiol. 286(5): F866-F874, 2004.  http://ajprenal.physiology.org/cgi/reprint/286/5/F866.pdf 

Just A., A.J.M. Olson, and W.J. Arendshorst. Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: Interactions with ETA receptors. Am. J. Physiol. - Renal Physiol., 286 (4): F660-F668, 2004.  http://ajprenal.physiology.org/cgi/reprint/286/4/F660.pdf 

Facemire, C. and W.J. Arendshorst.  Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation.  Am. J. Physiol. – Renal Physiol.  286(3): F546-F551, 2004.  http://ajprenal.physiology.org/cgi/reprint/286/3/F546.pdf 

Just A., A.J.M. Olson, and W.J. Arendshorst. Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: Interactions with ETA receptors. Am. J. Physiol. - Renal Physiol.286: F660-F668, 2004.   http://ajprenal.physiology.org/cgi/reprint/286/4/F660.pdf 

Fellner, S.K. and W.J. Arendshorst.  Endothelin A and B receptors on preglomerular vascular smooth muscle cells.  Kidney Int.  65: 1810-1817, 2004.  Click here 

Salomonsson, M. and W.J. Arendshorst.  Effect of tyrosine kinase blockade on norepinephrine-induced cytosolic calcium response in rat afferent arterioles.  Am. J. Physiol. – Renal Physiol.  286: F866-F874, 2004.  http://ajprenal.physiology.org/cgi/reprint/286/5/F866.pdf 

Just A., A.J.M. Olson, and W.J. Arendshorst. Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: Interactions with ETA receptors. Am. J. Physiol. - Renal Physiol., 286: F660-F668, 2004.  http://ajprenal.physiology.org/cgi/reprint/286/4/F660.pdf 

Facemire, C. and W.J. Arendshorst.  Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation.  Am. J. Physiol. – Renal Physiol.  286: F546-F551, 2004.  http://ajprenal.physiology.org/cgi/reprint/286/3/F546.pdf 

Bello-Reuss, E., and W.J. Arendshorst.  Kidney, Chapter 346, Volume 3, in Handbook of Cell Signaling, edited by Ralph Bradshaw and Edward Dennis, Elsevier Science, 2003, pp. 573-589.

 

 

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